![]() 13 from Italy described skin lesions in 14, 52 and 22 cases respectively. This was followed by another study from Italy which found skin rashes in 20.4% of 88 confirmed COVID-19 patients 10. The cutaneous manifestations in COVID-19 cases finds its first mention in an early study from China which reported skin symptoms in 0.2%–1.2% of their 1099 COVID-19 hospitalized cases 9. ![]() In this article, we have attempted to give a comprehensive overview of what has been learned an year into the pandemic on the epidemiology, clinical and histopathological features, pathophysiological mechanisms and clinical management of COVID-19 associated cutaneous manifestations. Besides, the exact incidence or prevalence remains largely unknown although some reports have given rough estimates. The evidence emerging from the literature published on the ongoing pandemic suggest that SARS-CoV-2 infection can manifest as heterogeneous cutaneous signs and symptoms in some patients and a number of researchers have attempted to classify these 8. Therefore, it becomes prudent for the dermatologists as well as primary care physicians to be aware of the cutaneous manifestations of COVID-19 to prevent misdiagnosis and missing the cases if skin involvement precedes other symptoms 7. Skin rashes associated with COVID-19 may clinically be misdiagnosed as some other unassociated dermatoses 3,6. Skin involvement is a rare and emerging subject in COVID-19 which may accompany or precede the common clinical symptoms as mentioned earlier. Fever, fatigue, dry cough, dyspnea, rhinorrhea, ageusia and anosmia are the common clinical signs of this novel disease 5. The cumulative number of global COVID-19 cases has surpassed the 120 million mark and has affected over 188 countries as on Ap4. As the virus spread rapidly across the globe, the World Health Organization (WHO) on March 11, 2020, declared the COVID-19 outbreak a pandemic 3. The disease caused by this virus was labelled as “coronavirus disease 2019” (COVID-19). Further research identified a new pathogen belonging to the family of coronaviruses (CoVs) and was designated as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which was isolated from respiratory tract samples of infected patients 2. In December 2019, a cluster of patients with unexplained pneumonia were reported from Wuhan, China 1. En este artículo hemos tratado de aportar una visión general amplia de lo que hemos aprendido en un año de inmersión en la pandemia en cuanto a epidemiología y características clínicas e histopatológicas, mecanismos patofisiológicos y manejo clínico de las manifestaciones cutáneas asociadas a la COVID-19. La incidencia o prevalencia exactas de las manifestaciones cutáneas asociadas a la COVID-19 son bastante desconocidas, y los mecanismos patofisiológicos siguen sin dilucidarse. ![]() Entre los signos extrapulmonares asociados a COVID-19 se han reportado cada vez más manifestaciones dermatológicas en las diferentes regiones geográficas. ![]() Los síntomas más comunes de la COVID-19 incluyen fiebre y enfermedad respiratoria. La pandemia por COVID-19 en curso, que surgió de la ciudad china de Wuhan en Diciembre de 2019, se ha propagado en 188 países, y ha infectado a más de 100 millones de personas a nivel mundial a lo largo de un año. La enfermedad por coronavirus de 2019 (COVID-19) es una situación sanitaria emergente causada por el “síndrome respiratorio agudo severo por coronavirus 2” (SARS-CoV-2). The exact incidence or prevalence of COVID-19 associated skin manifestation remains largely unknown and the pathophysiological mechanisms are still unclear. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasingly reported from different geographical regions. Most common symptoms of COVID-19 include fever and respiratory illness. The ongoing COVID-19 pandemic which emerged from the Chinese city of Wuhan in December 2019 has spread to over 188 countries and infected over 100 million people across the globe in over one year. Coronavirus disease-19 (COVID-19) is an emerging health situation caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2).
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